HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS
LATEST UPDATES » Vol 22, No 11, November 2018 – The Asian Cancer - War on liver cancer       » 2018 Nobel Prize in Physiology or Medicine winners       » Women more prone to selected chemotherapy side effects       » Tibetan fungus could help fight liver cancer       » Standards for TCM decoction to be applied globally       » RMB200 million donation to build Tsinghua University Biomedical Sciences Building      
BIOBOARD - ASIA-PACIFIC
Antibiotics overuse causes imbalanced gut microbiome
Antibiotics overuse leads to an imbalanced gut microbiome which is found to enhance cardiovascular mortality.

Dr Patrick C.H. Hsieh, lead author and research fellow at the Academia Sinica Institute of Biomedical Sciences (IBMS), Taiwan, and his research team found that overuse of antibiotics causes alteration in gut microbial composition.

The imbalanced microbiome affects the host immune system and impairs its function in cardiac repair after myocardial infarction. This increases myocardial infarction mortality. However, according to the researchers, the administration of Lactobacillus-based probiotics is able to enhance the post-infarction myocardial repair.

The number of human microbiota reside within and on human bodies is many-folds more than the number of cells comprising human bodies. These microbes co-exist with human from birth. The use of antibiotics suppresses some species and those favor the altered environment grow and flourish. The resulting dysbiosis, i.e. the altered microbial composition, cripples the immune response.

In the study, gut microbiota was depleted with antibiotics treatment, and the researchers observed drastically increased mortality in mouse myocardial infarction (MI) model. Most of these mice died with rupture in the left ventricle. The researchers found that the lack of short-chain fatty acids (SCFAs), one of the gut microbial metabolites, led to the findings.

SCFAs are the metabolites produced by gut microbiota through anaerobic fermentation of carbohydrates. They also serve as an important factor to modulate the function of immune cells. The injured myocardium stimulates the recruitment of macrophage and remove necrotic debris and apoptotic cells, followed by fibrosis to maintain cardiac structure. In the absence of SCFAs, cardiac repair mediated by immune cells is impaired and this increased the chance of cardiac rupture.

The team also suggests the supplementation of common Lactobacillus-based probiotics alters the gut microbial community in a favorable way that would enhance the function of cardiac repair.

In fact, gut microbiome is associated with not only cardiovascular diseases, but also obesity, diabetes, autoimmune diseases, cancer, and neuropsychiatric disorders.

The study was published online in Circulation on 8 October 2018.

Click here for the complete issue.

NEWS CRUNCH  
news Asia is the fastest growing region for nutraceuticals
news 2018 Nobel Prize in Physiology or Medicine winners
news Vitafoods Asia expands by 40 per cent in 2018
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  
COLUMNS  

APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Cancer - Therapies and strategies for better patient outcomes
July:
Water management - Technologies for biotech and pharmaceutical industries
August:
Regenerative technology - Meat of the future
September:
Doctor Robot - The digital healthcare revolution
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Lim Guan Yu
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com
Copyright© 2018 World Scientific Publishing Co Pte Ltd  •  Privacy Policy