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LATEST UPDATES » Vol 23, No 11, November 2019 – Evaluating cost effectiveness of genomic profiling       » Ion treatment offers new hope for cancer patients       » Empowering sustainability through innovation       » Meeting clinical needs in Asia with HealthTech       » The key in diagnosis and treatment       » Singapore's first private co-working laboratory and office space       » Singapore-based MedTech company announced as winner of 2019 Asia Pacific Showcase Competition at The MedTech Forum      
Vol 23, No. 11, November 2019For e-subscribers (PDF)
EYE ON CHINA
Discovery of cancer-causing gene reveals new anti-cancer therapy potential
Study published online in PNAS, describes a novel druggable oncogenic driver gene in human gastrointestinal stromal tumours (GISTs).

The research team led by Professor Wang Yuexiang of the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences, together with Professor Jonathan Fletcher from Brigham Women鈥檚 Hospital and Harvard Medical School used whole exome sequencing and reported recurrent genomic inactivated DEPDC5 gene mutations in GIST. DEPDC5 was shown to be a chromosome 22q-targeting tumour suppressor, silenced by mutations in GIST specifically.

Chromosome 22q deletions are frequent chromosomal abnormalities in human GISTs, occurring in approximately 50 percent of GISTs, and are thought to contribute to the pathogenesis of this disease. This research uncovers the crucial gene in chromosome 22q that is related to the genomic alterations.

The evidence showed that inactivation of DEPDC5 promotes rapid increase in GIST cells by activating the mTORC1 signalling pathway and subsequently preventing cell cycle arrest. They demonstrated that DEPDC5 modulates the sensitivity of GIST to KIT inhibitors, and combination therapy using the mTOR inhibitor and KIT inhibitor may work better in GIST patients with DEPDC5 inhibition.

Recurrent genomic alterations and functional data validate DEPDC5 as a tumour suppressor contributing to GIST progression and biologically relevant target of frequent chromosome 22q deletions. The DEPDC5-inactivated mutation will be able to serve as a predictive course of GIST as they are associated with aggressive GISTs, where they promote GIST progression and reduce sensitivity to KIT indicators.

The inactivation of DEPDC5 gene has also been found to be associated with the disease mechanism of focal epilepsy. Thus, highlighting that recent therapeutic developments for focal epilepsy could also serve as anti-cancer drugs.

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NEWS CRUNCH  
news Natural Extracts Innovated, Transformed and Diversely Laid Out to Embrace the Blue Ocean Market of Big Health
news The Proteona Oncology Challenge using ESCAPETM Single Cell Proteogenomic Analysis
news New computational fluid dynamics solution for modeling aerosol mixtures in biomedical and environmental research
news Medial Fair Thailand opened on 11th September 2019 with a focus on future-proofing Thailand's healthcare industry to meet the challenges and opportunities of the next decade
PR NEWSWIRE  
Asia Pacific Biotech News
SPOTLIGHT  
LIFE OF A SCIENTIST  

APBN Editorial Calendar 2019
January:
Taiwan Medical tourism
February:
Marijuana as medicine — Legal marijuana will open up scientific research
March:
Driven by curiosity
April:
Career developments for researchers
May:
What's cracking — Antibodies in ostrich eggs
June:
Clinical trials — What's in a name?
July:
Traditional Chinese medicine in modern healthcare — Integrating both worlds
August:
Digitalization vs Digitization — Exploring Emerging Trends in Healthcare
September:
Healthy Ageing — How Science is chipping in
October:
Disruptive Urban Farming — Microbes, Plasmids, and Recycling
November:
Evaluating cost effectiveness of genomic profiling
Editorial calendar is subjected to changes.
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