HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, No. 8, August 2016 – Novel Technologies for Antibody Drug Discovery in Japan       » Global Experts Convene to Discuss China's Plan for Diabetes Prevention and Rehabilitation in 2016       » Butterflies Offer Climate Scientists Ecological Insights       » Thermal Stability of Camelid Single Domain VHH Antibody       » That Gut Feeling: How A Healthy Digestive System Has Everything To Do With It       » World Heart Day - At the Heart of Health      
BIOBOARD - NORTH AMERICA
FEI unveils broad correlative microscopy solution set for cell biologists
FEI has announced a suite of solutions for correlative light and electron microscopy (CLEM). New methods in correlative microscopy from FEI bring data from different imaging techniques together automatically in minutes, giving cell biologists the precise information they need, when they need it. Scientists believe that correlating information from the cellular down to the molecular level will lead to breakthrough discoveries that improve their understanding and treatment of diseases, such as cancer, AIDS, and Parkinson's.

“Light microscopy encompasses a broad and varied set of techniques and methodologies, each with its own requirements for correlation. One workflow does not fit all,” said Dominique Hubert, Vice President and General Manager of FEI's Life Sciences Business Unit. “We have developed a set of workflows that are flexible enough to cover a significant share of the possible applications. And we are committed to extending that coverage as the science develops.”

Electron microscopy (EM) offers extremely high image resolution—1,000 or more times better than light microscopes. Light microscopes (LM) offer a wide variety of specialized techniques, such as fluorescent labeling, that can identify a single molecule or structure within a large, complex environment like the interior of a living cell. Correlating between the two techniques allows scientists to use LM to find the target and EM to explore its form and function. Correlative microscopy allows investigators to find a feature of interest faster in the EM, gain additional information about its structure down to the molecular scale, and understand relationships between the feature and its larger scale context.

 Oregon Health and Science University's Professor Joe Gray, who is based in Portland, Oregon, said: “Biologists want to understand the molecular events and interactions that constitute the larger scale processes we observe in cells and tissues. This will require integration of information from multiple resolution scales, for example, ultrastructural analysis of cells that reside in specific microenvironmental niches. The iCorr system allows us to quickly find fluorescently stained cells of interest using fluorescence microscopy and followed by detailed structural analysis using electron microscopy.”

Roger Wepf, Director of electron microscopy at the Swiss Federal Institute of Technology in Zurich adds, “With CorrSight, sample preparation for the electron microscope is integrated with the light microscope, using on-board fixation. We identify the target structure and prepare the sample on the CorrSight light microscope platform, then transfer the sample to the electron microscope and, with a few clicks of the mouse, navigate directly the target. This is exactly what we have been missing since it allows us to reduce manual, tedious work and improve reproducibility. CorrSight and MAPS will open new applications in correlative microscopy that were not possible before.”

Hubert added, “At this point, we have only glimpsed the potential of correlative microscopy. It promises to open whole new avenues of investigation into the relationships between structure and function in biological systems at the finest scale. FEI is committed to leading the expansion of this applications space by developing correlative workflow solutions for the broadest range of techniques and methodologies.”

Click here for the complete issue.

NEWS CRUNCH  
news World Population Day 2016
news NUS Student Clinches Top Prize at National Smart Mapping Competition with Cutting-Edge Food Security Solution
news Gather China & World Pharmaceutical Entrepreneurs, Create a New Chapter of Chinese Pharma Industry
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Lady Ganga: Nilza'S Story
COLUMNS  
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Leading-Edge ONCOLOGY
May:
Healthcare Systems & Policies in Asia
June:
Medical Devices & Healthcare Technology
July:
Water Technology and Management
August:
Novel Technologies for Antibody Drug Discovery in Japan
September:
Infectious Diseases
October:
Medical Tourism
November:
Big Data in Healthcare
December:
Evidence-based TCM
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Carmen
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com or Mr Edward
Copyright© 2016 World Scientific Publishing Co Pte Ltd  •  Privacy Policy