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LATEST UPDATES » Vol 22, No 06, June 2018 – Cancer - Therapies and strategies for better patient outcomes       » Gardasil 9 supply running short in Hong Kong       » China helps Tajikistan tackle grassland degradation       » Immuno-oncology trials in China surge more than 50 per cent       » Yeast for industrial biotechnology       » Uncontrolled hypertension in rural communities      
EYE ON CHINA
New analytical method for uleine alkaloids having anticancer activity
Two uleine alkaloids were isolated from the trunk bark of Winchia calophylla which exhibited anticancer activity. Their potential applications in clinical experiments necessitate the development of a new method for the analysis of uleine alkaloids.

In order to establish a reliable, fast and low-cost analysis method, researchers in Prof. Wu Zhijun lab at the Chengdu Institute of Biology, Chinese Academy of Sciences investigated their structural characteristic using electrospray tandem mass spectrometry (ESI-MS/MS) method. Dr. Wu and his colleagues revealed fragmentation rules of uleine alkaloids and found that a Retro Diels Alder (RDA) reaction played a significant role in their skeletal fragmentation. The corresponding information can be used for the rapid analysis of uleine alkaloids in complex mixtures from plant extract.

The method is a rapid and new analysis method for the identification of uleine alkaloids in complex matrices and also provides a new way for their total synthesis.This research entitled “Electrospray ionization tandem mass spectrometry of uleine alkaloids” was published in Rapid Commun.Mass Spectrom. on September 19, 2012.

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APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Cancer - Therapies and strategies for better patient outcomes
July:
Water management / Vaccination
August:
Regenerative medicine / Biotech start ups
September:
Digital healthcare / 3D printing
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
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