Phylogica Ltd, a leading Australian peptide drug discovery company, announced that it has entered an agreement with Bio-Link Australia Pty. Ltd., a specialist life sciences business development company, to commercialize a family of anti-inflammatory PhylomerÒ peptides for pharmaceutical use. Under the terms of the agreement, Bio-Link will work with Phylogica to monetize these assets through out-licensing or disposal of the Phylomer peptides to a pharmaceutical or biotechnology company.
The family of anti-inflammatory Phylomer peptides, including lead candidates PYC35, PYC36, PYC38 and PYC98, target the AP-1 pathway, which is a crucial mediator of inflammation in various diseases. The AP-1 pathway plays a critical role in neuronal cell death caused by stroke and traumatic brain injury, and lung inflammation resulting from acute respiratory distress syndrome (ARDS) and septic shock. The family of Phylomer peptides have demonstrated efficacy in multiple preclinical models for stroke, traumatic brain injury and ARDS.
Phylogica has developed a strong patent estate around this family of peptides. In addition to granted patents in Australia, the USA and Europe covering composition of matter of several of these peptides, a patent for their use in treatment of neuronal conditions has been granted in the USA. Phylogica has also recently been allowed a European patent, which covers formulations of these peptides for the treatment of ischemia.
The commercialization efforts of Phylogica and Bio-Link will be supported by a grant of $20,000 from the Western Australian government under the Innovation Vouchers Program (IVP). The IVP is part of the government’s Translating Research Scheme with the objective to translate research into economic, social and environmental outcomes for industry, government and the community of Western Australia. The major aim of the IVP is to enable small-to-medium enterprises to have access to, and establish collaborative relationships with, research providers and/or specialist commercialization support services.
Dr. Paul Watt, Phylogica’s Chief Executive Officer, commented on the news: “This non-dilutive grant income from the government has provided us with an opportunity to engage Bio-Link to support ongoing efforts to monetize our portfolio of Phylomer peptides targeting the AP-1 pathway. We believe that these unique peptides have substantial potential as drug candidates for multiple diseases and conditions with unmet medical need. The Bio-Link team comprises experienced industry executives with an excellent track record in securing partners or acquirers for biotech assets. We look forward to working with them to accelerate partnerships around these Phylomers, while Phylogica’s management team maintains its focus on building the Company’s drug discovery alliance activities.”
Paul Field, Bio-Link’s Executive Chairman, said: “We are excited by the opportunity to work with Phylogica and to partner this family of AP-1 inhibitory peptides with companies seeking new potential therapies for stroke, traumatic brain injury and ARDS.”
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