HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, Volume 2, February 2016 Biomedical Research Governance       » Tissue banking in Singapore — An Evolving Enterprise       » China Recognizes Prominent Scientists and Stresses on Innovation       » NUS Researchers Uncover Potent Parasite-killing Mechanism of Nobel Prize-Winning Anti-Malarial Drug       » A New Water Robot "Born" to Detect Water Quality       » Probing the Mystery of How Cancer Cells Die       » Researchers Find Link between Processed Foods and Autoimmune Diseases       » Unravelling the Genetics of Pregnancy and Heart Failure      
EYE on CHINA
HKU finds novel coronavirus can infect humans respiratory tract even better than SARS-CoV
HKU research team reveals how the novel coronavirus (HCoV-EMC) causes disease in human respiratory tract and the potential options for clinical treatment. By using human lung tissues maintained in culture, the researchers discover that the novel coronavirus is as virulent or more virulent that SARS coronavirus in causing lung damage. This research has recently been published in the international virology journal, Journal of Virology.

Researchers at the Centre of Influenza Research of the School of Public Health, the Department of Pathology and the State Key Laboratory of Emerging Infectious Diseases of The University of Hong Kong Li Ka Shing Faculty of Medicine, lead the research. One of the key members of the team, Dr. Michael Chan Chi-wai, Assistant Professor of the School of Public Health says, “How HCoV-EMC causes severe disease and death in humans is still unknown." We have made use of our human lung ex vivo explant culture system to show for the first time how the novel coronavirus cause human disease in lung and how it may spread to other organs. Our team also finds that interferon treatment can suppress the virus infection in the lung. It brings insight to potential treatment strategies for the novel coronavirus.”

The researchers use human lung tissues maintained in culture to compare infection with the novel coronavirus (HCoV-EMC), SARS coronavirus (SARS-CoV) and the common cold virus 229E. They find that the novel coronavirus infects and replicates in human alveolar type I and type II epithelial cells in the lung and it multiplies even faster than the SARS coronavirus causing severe lung injury.

Type I alveolar epithelial cells are crucial for oxygen exchange in the lungs and damage to these cells leads to difficulty in breathing. Type II alveolar epithelial cells are the key cell for regeneration and repair of damaged lung tissues and damage to these cells will prevent repair processes that allow the lung to recover from injury or infection.

Taken together, this explains the severe pneumonia caused by this virus and the severity of disease. It further shows that the novel HCoV-EMV is as virulent or more virulent than SARS-CoV in causing lung damage. They also point out that the virus infects the cells lining the blood vessels of the lung (endothelial cells), suggesting that the virus may spread through the blood stream to affect organs distant from the respiratory tract.

To explore the possible treatment strategies, the research also addresses the pathogenesis of the novel coronavirus. The result demonstrates that the novel coronavirus avoids activating the human lung interferon responses, which are the first-line host defense system to defend against viral infection, and allows the virus to continue to replicate and cause damage to the lung. On the other hand, the virus infection in the lung can be suppressed by interferon treatment, suggesting that this is a treatment option that may be beneficial in treating humans with novel coronavirus infected disease.

Click here for the complete issue.

NEWS CRUNCH  
news EmTech Asia Opens: Features 50 speakers on innovation and emerging technologies
news Russia's only project to supply local high-tech anti-cancer drugs abroad continues with the first shipment to Vietnam
news Wheat Genome Sequencing Gets Major Boost
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Primates in Biomedical Research
COLUMNS  
\
APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Cancerology / Oncology
May:
Guest Editorial - Antibody Informatics In Japan
June:
Medical Devices and Technology
July:
Water Technology
August:
Occupational Health
September:
Olympics: Evolution of Sports
October:
Respiratory: Seasonal flu viruses
November:
Tobacco Smoking
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» Editorial Enquiries: biotech_edit@wspc.com
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   Ms PoPo Kwok or Ms Sok Ching Lim/td>
Copyright© 2015 World Scientific Publishing Co Pte Ltd  •  Privacy Policy