HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, No. 5, May 2016 – Healthcare Systems & Policies in Asia       » Understanding Healthcare Policies in the Philippines: Cancer Care       » Young Innovators under 35       » Healthcare Cost Effectiveness in Singapore       » ASLAN Pharmaceuticals Opens China Office       » A Journey Inside the Human Body       » Treatment Brings New Hope for Patients Suffering From Fatal Lung Disease      
BIOBOARD - EUROPE
Shaping the stem cell genome
Stem cell genes seek each other in the cell nucleus. So a study by the Hubrecht Institute in Utrecht, the Netherlands, has found, published in Nature. “It's a new way of looking at DNA.”

Prof. Dr. Wouter de Laat of the Hubrecht Institute and his colleagues have shown that DNA strings in embryonic stem cells are folded in a unique manner. The DNA appears to be folded in such a way that all ‘stem cell genes’ are located close to each other. The activity of these genes ensures that stem cells remain stem cells and they do not change into other types of cells.

The so-called stem cell factors are responsible for the special DNA folding in embryonic stem cells. These are proteins that can only be found in stem cells and with which normal cells can be reprogrammed into stem cells. Without these proteins, stem cells lose their unique DNA folding. The proteins attach to DNA strings in various places and ‘pull’ the strings together.

“We don’t know exactly why these genes have to be so close to each other”, says De Laat. “But of course it's entirely possible that this will allow the stem cell genes to be sequenced in an improved and more stable manner. It makes stem cells more robust.”

The findings by De Laat and his colleagues underline the importance of the three-dimensional organization of DNA strings. It was previously thought that only the sequence of the genetic letters in the DNA was important. But it seems that it is important for genes with a comparable role to literally be close to each other. “This is a new way of looking at DNA. The spatial organization of the DNA actually forms an additional control layer.”

Click here for the complete issue.

NEWS CRUNCH  
news Gather China & World Pharmaceutical Entrepreneurs, Create a New Chapter of Chinese Pharma Industry
news Mundipharma's New Betadine® Facility to Meet Regional Healthcare Challenges
news STRATASYS launches World's First Full-ColoUr Multi-material 3D PRINTER - THE J750 - In Singapore
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  
COLUMNS  
APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Leading-Edge ONCOLOGY
May:
Healthcare Systems & Policies in Asia
June:
Medical Devices and Digital Health Technology
July:
Water Technology
August:
Guest Editorial - Antibody Informatics In Japan
September:
Infectious Diseases
October:
Medical Tourism
November:
Biomedical Imaging Technology
December:
Food Technology
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» Editorial Enquiries: biotech_edit@wspc.com
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   Ms PoPo Kwok or Ms Sok Ching Lim/td>
Copyright© 2015 World Scientific Publishing Co Pte Ltd  •  Privacy Policy