HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, No. 9, September 2016 – Infectious Diseases       » Curcumin Derivatives May Prevent Alzheimer's Disease by Promoting Amyloid-β Clearance       » Varian Chosen to Equip First Government Owned Proton Centre in China       » Medtronic and SingHealth Collaborate on a Centre of Excellence to Fight Diabetes       » NCCS Awards Contract for Proton Beam Therapy System to Hitachi Asia      
BIOBOARD - EUROPE
Shaping the stem cell genome
Stem cell genes seek each other in the cell nucleus. So a study by the Hubrecht Institute in Utrecht, the Netherlands, has found, published in Nature. “It's a new way of looking at DNA.”

Prof. Dr. Wouter de Laat of the Hubrecht Institute and his colleagues have shown that DNA strings in embryonic stem cells are folded in a unique manner. The DNA appears to be folded in such a way that all ‘stem cell genes’ are located close to each other. The activity of these genes ensures that stem cells remain stem cells and they do not change into other types of cells.

The so-called stem cell factors are responsible for the special DNA folding in embryonic stem cells. These are proteins that can only be found in stem cells and with which normal cells can be reprogrammed into stem cells. Without these proteins, stem cells lose their unique DNA folding. The proteins attach to DNA strings in various places and ‘pull’ the strings together.

“We don’t know exactly why these genes have to be so close to each other”, says De Laat. “But of course it's entirely possible that this will allow the stem cell genes to be sequenced in an improved and more stable manner. It makes stem cells more robust.”

The findings by De Laat and his colleagues underline the importance of the three-dimensional organization of DNA strings. It was previously thought that only the sequence of the genetic letters in the DNA was important. But it seems that it is important for genes with a comparable role to literally be close to each other. “This is a new way of looking at DNA. The spatial organization of the DNA actually forms an additional control layer.”

Click here for the complete issue.

NEWS CRUNCH  
news Enterprise meets technology: More than 300 enabling innovations showcased at TechInnovation
news CPhI's Pre-Connect Congress outlines current trends in pharma
news World Population Day 2016
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Lady Ganga: Nilza'S Story
COLUMNS  
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Leading-Edge ONCOLOGY
May:
Healthcare Systems & Policies in Asia
June:
Medical Devices & Healthcare Technology
July:
Water Technology and Management
August:
Novel Technologies for Antibody Drug Discovery in Japan
September:
Infectious Diseases
October:
Medical Tourism
November:
Big Data in Healthcare
December:
Orthopaedics
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Carmen
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com
Copyright© 2016 World Scientific Publishing Co Pte Ltd  •  Privacy Policy