HOME ABOUT CONTACT PREVIOUS ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Intelligent Sensor Informs You to Change a Diaper via SMS       » University of Manchester & A*STAR ongoing partnership- Joint PhD programme       » Philippines Healthcare & New Digital Platform, MyDoc.       » Tapping on ASEAN'S Healthcare Opportunities through Singapore       » ASEAN: The New Playing Field for Global Medical Device Companies       » The Burden of Great Potential: the ASEAN Economic Community & Biopharmaceuticals       » When there is no Queen in the house, Asian Hive Bees Avoid Risky Foraging for Reproduction       » XELJANZTM (Tofacitinib Citrate), A new class of treatment for Rheumatoid Arthritis Approved in Singapore      
BIOBOARD - AUSTRALIA
E. coli jabs toxin into gut cells

Scientists have figured out how virulent E. coli bacteria block a pathway that would normally protect the gut from infection.

These infections are particularly serious in young children and can result in diarrhea and other complications such as kidney damage.

The role of this pathway in fighting gut infection was previously unknown but defects in it are associated with inflammatory bowel disease.

The research, published in Nature, improves our understanding of what happens when this pathway doesn’t work as well as it should, says lead author Professor Elizabeth Hartland from the University of Melbourne’s microbiology and immunology department.

“This research provides a model where we can look at how these bacteria switch off a critical pathway in our body that helps fight infection and contributes to normal intestinal function,” she says.

“Using this fundamental knowledge, we can conduct further studies and work towards improving therapies and treatments for people with inflammatory bowel disease, which affects around 5 million people worldwide.”

The researchers found the diarrhea-causing bacteria use a needle-like structure to inject a toxin into the gut cell that blocks cell death. This allows the bacteria to survive and spread in the gut, causing a range of diseases.

The injected toxin paralyzes the infected cell’s ability to send messages to immune cells that would normally sense and eliminate dangerous microbes from the body as well as alert the broader immune system to mount a response to the infection.

“This is a significant contribution to global research in this field as the role of this pathway in intestinal defense and the way bacteria go about blocking this pathway was not known.”

Diarrheal infections are predominantly a problem in developing countries where sanitation is poor, yet cases of virulent E. coli also occur in developed countries.

Click here for the complete issue.

EDITORS' CHOICE  

Credits to: American Chemical Society
COLUMNS  

APBN Editorial Calendar 2015
Trends and Predictions for 2015 Robotics in Healthcare Nutrition Universal Health Coverage
Start-Up Biotech Companies Preventative and Translational Medicine Biofuels ASEAN Economic Community and Asia's Life Sciences Industry
Big Data: Healthcare and Drug Development Antibody Engineering in Japan Christmas Edition
APBN Editorial Calendar 2016
Korea's Biotechnology Industry Nutrition and Allergies: Are we, Too Clean? Medical Devices and Technology: Innovation that leaves an Inspiration Tobacco Smoking: The 'Real' Cost of One Cigarette
Life-Saving Opportunities: A Guide to Regenerative Medicine Occupational Health Water Technology Olympics: Evolution of Sports
Respiratory: Seasonal flu viruses
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» Editorial Enquiries: biotech_edit@wspc.com
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   Ms PoPo Kwok or Ms Sok Ching Lim
Copyright© 2015 World Scientific Publishing Co Pte Ltd  •  Privacy Policy