HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, No. 8, August 2016 – Novel Technologies for Antibody Drug Discovery in Japan       » Global Experts Convene to Discuss China's Plan for Diabetes Prevention and Rehabilitation in 2016       » Butterflies Offer Climate Scientists Ecological Insights       » Thermal Stability of Camelid Single Domain VHH Antibody       » That Gut Feeling: How A Healthy Digestive System Has Everything To Do With It       » World Heart Day - At the Heart of Health      
BIOBOARD - UNITED STATES
Team uncovers HIV's secret survival trick
HIV, the virus that causes AIDS, has an alternate way to replicate, researchers have discovered.

“Although this is not the virus’ main method for replicating, having this option available can help HIV survive,” says David N. Levy, an associate professor of science and craniofacial biology at the New York University College of Dentistry.

“These new findings suggest one mechanism by which HIV may be surviving in the face of antiviral drugs, and suggests new avenues for research into eliminating infection,” adds Levy, who led the research published in the Journal of Virology.

For decades, scientists have been confident that HIV-1, the virus that causes AIDS, must insert its genetic material into a cell's DNA in order to reproduce. This process, called “integration,” makes the virus a permanent part of the cell.

Some of these infected cells can remain as long as the person is alive, and this is one reason why HIV-positive individuals must remain on anti-HIV drugs for life.

HIV-1 can sometimes skip this integration step entirely, the researchers discovered.

The integration step is highly inefficient and actually fails up to 99 percent of the time, leaving most viruses stranded outside of the safe harbor of cell's DNA. The assumption was that these stranded, or “unintegrated”, viruses were unable to reproduce, but Levy's team has found that if the conditions are right, they can generate new viruses that infect new cells.

The unintegrated viruses can survive for many weeks in cells, allowing HIV to “hide out” in a dormant state. The ability of HIV-1 to go dormant helps it avoid elimination by antiviral drugs and immune responses.

“There is intense interest by researchers in the idea that new drugs might be developed to help to completely eliminate the virus from infected individuals,” says Levy. “We think that the new replication mechanism we have found could provide a target for drugs designed to eliminate infection.”

The National Institutes of Health supported the work.

Source: New York University

Click here for the complete issue.

NEWS CRUNCH  
news CPhI's Pre-Connect Congress outlines current trends in pharma
news World Population Day 2016
news NUS Student Clinches Top Prize at National Smart Mapping Competition with Cutting-Edge Food Security Solution
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Lady Ganga: Nilza'S Story
COLUMNS  
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Leading-Edge ONCOLOGY
May:
Healthcare Systems & Policies in Asia
June:
Medical Devices & Healthcare Technology
July:
Water Technology and Management
August:
Novel Technologies for Antibody Drug Discovery in Japan
September:
Infectious Diseases
October:
Medical Tourism
November:
Big Data in Healthcare
December:
Evidence-based TCM
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Carmen
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com or Mr Edward
Copyright© 2016 World Scientific Publishing Co Pte Ltd  •  Privacy Policy