HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Volume 20, No. 8, August 2016 – Novel Technologies for Antibody Drug Discovery in Japan       » Global Experts Convene to Discuss China's Plan for Diabetes Prevention and Rehabilitation in 2016       » Butterflies Offer Climate Scientists Ecological Insights       » Thermal Stability of Camelid Single Domain VHH Antibody       » That Gut Feeling: How A Healthy Digestive System Has Everything To Do With It       » World Heart Day - At the Heart of Health      
BIOBOARD - CAMBODIA
Study tags cause of malaria drug resistance in Cambodia
A study has identified mutations in the malaria parasite that have perplexed scientists in recent years and raised fears of drug-resistant malaria potentially spreading unchecked through tropical countries.

The study was based on a five-year research project that created malaria mutations in a lab based on a sample retrieved from a malaria patient in Tanzania.

The researchers found mutations inside the so-called 'propeller' domain of the Kelch, or K13 protein, potentially offering clues into how resistance to artemisinin has developed in Cambodia, where the first case of resistant malaria strains were discovered in the early 2000s.

Drug-resistant strains were later discovered in Myanmar, Thailand and Vietnam, and researchers and health officials now worry that the strains could spread to Bangladesh, India and countries in Africa.

"It clearly demonstrates that a mutation in a specific Kelch-propellor protein results in resistance to artemisinin," Ian Graham, head of the biology department at the University of York in Britain, says of the study.

Graham led a team of scientists that published a genetic map of Artemisia annua plant, the source of artemisinin which is the most potent drug against the malaria parasite. Artemisinin is made from the sweet wormwood plant and used in traditional Chinese medicines.

The WHO recommends a combination of artemisinin and other drugs as the first-line treatment for basic malaria infections. It says that artemisinin typically reduces a patient's "parasite load" while a partner drug eliminates remaining parasites, typically curing patients in two days.

According to the study, the studies in Cambodia in the early 2000s documented cases in which patients were cured after five days, or not at all, by artemisinin treatments. The WHO says resistance is linked to poor treatment, substandard versions of artemisinin, and reluctance by some patients to complete their treatment regimens.

Graham explains that the identification of a molecular marker will allow scientists to track the spread of resistance to artemisinin, and for futureresearch to help understand how the resistance developed and possibly come up with ways to overcome such resistance.

"We do not understand the precise mode of action of artemisinin and such research is important," he adds. "The Kelch propellor protein could be interacting directly or indirectly with the drug."

Mike Ives
Source: Science Development Network

Click here for the complete issue.

NEWS CRUNCH  
news CPhI's Pre-Connect Congress outlines current trends in pharma
news World Population Day 2016
news NUS Student Clinches Top Prize at National Smart Mapping Competition with Cutting-Edge Food Security Solution
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Lady Ganga: Nilza'S Story
COLUMNS  
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2016
January:
Guest Editorial - Biotechnology In Korea
February:
Guest Editorial - Biomedical Research Governance
March:
Guest Editorial - Life-Saving Opportunities: A Guide to Regenerative Medicine
April:
Leading-Edge ONCOLOGY
May:
Healthcare Systems & Policies in Asia
June:
Medical Devices & Healthcare Technology
July:
Water Technology and Management
August:
Novel Technologies for Antibody Drug Discovery in Japan
September:
Infectious Diseases
October:
Medical Tourism
November:
Big Data in Healthcare
December:
Evidence-based TCM
Editorial calendar is subjected to changes.
– Editor: Carmen, Jia Wen Loh
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Carmen
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com or Mr Edward
Copyright© 2016 World Scientific Publishing Co Pte Ltd  •  Privacy Policy