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Discovery of mechanism by which sex hormone regulates aggressive behavior
A group led by Professor Kazuyoshi Tsutsui and Research Associate Takayoshi Ubuka, of the Waseda University Center for Advanced Biomedical Sciences, has discovered a hormonal mechanism for controlling aggressiveness in male birds.

Male aggressiveness has long been thought to depend on androgen, a male sex hormone produced in the testes. However, previous research suggested that a synthetic enzyme (aromatase) can convert androgen into female sex hormone (estrogen) in the brain and regulate male aggressiveness.

In 2000, Professor Tsutsui et al. discovered a new hypothalamic hormone (gonadotropin-inhibitory hormone, GnIH; a type of neuropeptide) in the brain which inhibits reproduction. Later, Ubuka et al. demonstrated that GnIH can inhibit aggressive behavior.

The current research, in order to understand the mechanism of GnIH inhibiting aggressiveness, involved a series of experiments using quail, an aggressive species of bird, as a model. When GnIH was injected into a male's brain, activity of aromatase was increased, and the quantity of estrogen in the brain was greatly increased.

Next, when highly concentrated estrogen was injected, aggressiveness of the male quail was greatly decreased. Further, it became clear that neurons which synthesize estrogen have the receptor for GnIH.

This research shows that GnIH acts on the neurons which synthesize estrogen, to greatly increase production of estrogen and greatly decrease aggressiveness in male quail. Hence it is thought that when GnIH causes an extreme increase in estrogen synthesis, this creates an excess of estrogen in the brain and curbs male aggressiveness.

This research has explained a mechanism of regulating aggressiveness. Abnormally high aggressiveness is a major cause of instability in human society. This research provides a model for explaining behavior of quail, an aggressive bird species, but future work, by looking for a similar mechanism in humans, may lead to a method for regulating spikes in aggressiveness in humans, and thereby contribute to peace and order in society.

Source: JCN Newswire

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APBN Editorial Calendar 2018
January:
Obesity / Outlook for 2018
February:
Searching for the fountain of youth
March:
Women in Science - Making a difference
April:
Digestive health in the 21st century - Trust your guts
May:
Dental health - The root to good health
June:
Cancer - Therapies and strategies for better patient outcomes
July:
Water management / Vaccination
August:
Regenerative medicine / Biotech start ups
September:
Digital healthcare / 3D printing
October:
Bones / Breast cancer
November:
Liver health / Top science research nations & institutions
December:
AIDS / Breakthrough of the year/Emerging trends
Editorial calendar is subjected to changes.
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