HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS CONFERENCE CALENDAR
LATEST UPDATES » Vol 21, No 10, September 2017 – Cardiovascular diseases       » Test strips for cancer detection get upgraded with nanoparticle bling       » Smart nano-pesticide to combat soil and water contamination       » China plans to launch "brain project" by year end       » UNAIDS encourages Chinese to produce drugs for Africa       » Korea-Singapore Healthcare Incubator to support Korean firms in Singapore and Southeast Asia       » Nanomaterial wrap for improved tissue imaging      
BIOBOARD - EUROPE
Understanding heart failure at the cellular level
A team of researchers at the University of Florence in Italy and the University of Connecticut Health Center have used a multidisciplinary approach to provide an unprecedented glimpse of what happens to the heart during an "infarction" — a heart attack — by looking at how the attack affects electrical activity and calcium release in heart cells.

"Thanks to this method, we found electrical abnormalities and non-homogenous calcium release across failing cells," explained Claudia Crocini, who presented the research at the 58th Annual Biophysical Society Meeting. "Our findings provide insight on the relationship between heart failure and asynchronous calcium release, a major determinant of cardiac contractile dysfunction and arrhythmias."

Heart disease is the leading cause of death in the United States, accounting for a quarter of all American deaths each year and costing the healthcare system more than $100 billion annually. According to the American Heart Association, there are 5.7 million Americans who are living with heart failure and 670,000 new cases are diagnosed annually.

Seeking to understand what happens to heart cells during heart failure, Crocini and her colleagues took a multidisciplinary approach involving physicists and biologists that made it possible to study the two main features of cardiac cells, voltage and calcium release, during heart failure with an unprecedented temporal and spatial resolution.

To clarify the link between electrical abnormalities and calcium-dependent arrhythmias, the team combined the advantages of an ultrafast random access multi-photon (RAMP) microscope with a double staining approach to optically record action potential and, simultaneously, the corresponding local Ca2+-transient in different positions across the cardiac cells.

Both beat-to-beat and spatial variability of Ca2+-transient kinetics were increased in heart failure. Through simultaneous recording of AP and Ca2+-transient the team was able to probe the spatio-temporal variability of Ca2+-release, disclosing an unexpected uncoupling between membrane depolarization and Ca2+-release in heart failure.

"While there is not a direct bench-to-bedside connection for this research, it is only by studying the basic pathomechanisms of heart failure that we can even begin to think about new diagnostic or treatment approaches," said Crocini.

Click here for the complete issue.

NEWS CRUNCH  
news $1.7 million awarded to Australian biomedical researchers through philanthropic Ramaciotti Foundations
news Genetically boosting the nutritional value of corn could benefit millions
news Inhibitor Pariet obtained approval of additional dosage in Japan for maintenance therapy of proton pump inhibitor resistant reflux esophagitis
PR NEWSWIRE  
Asia Pacific Biotech News
EDITORS' CHOICE  

Lady Ganga: Nilza'S Story
COLUMNS  
Subscribe to APBN E-Newsletter
Find us under 'Others' option to receive APBN e-newsletters thrice a month!

APBN Editorial Calendar 2017
January:
Healthcare Focus: LUNGS
February:
War on CANCER
March:
Get to Know TCM
April:
Diabetes: The Big Picture
May:
The Piece of Your Mind - Brain Health/Science
June:
Advocacies in Support of Rare Disease Patients
July:
Food Science & Technology
August:
Eye – the Window to your Soul
September:
Infectious Diseases
October:
A change of heart — Cardiovascular diseases
November:
Diseases threatening our Children
December:
Skin Diseases/Allergic Reactions
Editorial calendar is subjected to changes.
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Lim Guan Yu
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com
Copyright© 2017 World Scientific Publishing Co Pte Ltd  •  Privacy Policy