HOME ABOUT CONTACT AVAILABLE ISSUES SUBSCRIBE MEDIA & ADS
LATEST UPDATES » Vol 23, No 11, November 2019 – Evaluating cost effectiveness of genomic profiling       » Ion treatment offers new hope for cancer patients       » Empowering sustainability through innovation       » Meeting clinical needs in Asia with HealthTech       » The key in diagnosis and treatment       » Singapore's first private co-working laboratory and office space       » Singapore-based MedTech company announced as winner of 2019 Asia Pacific Showcase Competition at The MedTech Forum      
BIOBOARD - ASIA-PACIFIC
Identification of specific proteins can aid in development of novel therapeutic targets for heart diseases
Researchers from Duke-NUS have developed the first genome-wide dataset on protein translation during fibroblast activation during cardiac fibrosis.

Using cutting-edge technologies, researchers at Duke-NUS Medical School, Singapore, have revealed a network of RNA-binding proteins (RBP) that play a key role in the formation of disease-causing fibrous tissue in the heart. Their findings, published in the journal Circulation, could assist in the search for new therapeutic targets.

Cardiac fibrosis, a condition characterised by scarring in the heart, is caused by the activation of fibre-producing cells called fibroblasts. The transformation of fibroblasts to myofibroblasts, will lead to the thickening and stiffening of the heart wall, making it less contractile and thus less efficient in pumping blood throughout the body.

Computational geneticist Dr Owen Rackham, corresponding author of the study and Assistant Professor in the Cardiovascular and Metabolic Disorders (CVMD) Programme at Duke-NUS explains, “Despite the serious risk and high prevalence of cardiac fibrosis, existing therapies are ineffective and there is an unmet need for new therapeutic approaches to prevent, limit, or reverse the condition.”

The team of researchers from Duke-NUS and colleagues in Germany and the UK investigated the processes that regulate the transcription of DNA code into RNA, and the translation of that code from RNA for protein synthesis during the transformation of fibroblasts into myofibroblasts.

Specifically, the researchers found RBPs play critical roles in the fibroblast-to-myofibroblast transformation. RBPs target RNA, affecting the translation of its code during protein synthesis. Inhibiting two of these RBPs, called PUM2 and QKI, limited the transformation of fibroblasts into myofibroblasts.

“We found a staggering one-third of all genes undergo translational regulation during this pathogenic transition,” highlighted Ms Sonia Chothani, first author of the study and a PhD student at Duke-NUS. “All these gene expression changes are missed or misinterpreted in traditional RNA-based studies.”

From this study, the researchers recommend future research to carefully reveal the interdependencies and cross-interactions in the various stages of gene expression to have a better understanding of the regulatory process leading to disease manifestation.

Click here for the complete issue.

NEWS CRUNCH  
news Natural Extracts Innovated, Transformed and Diversely Laid Out to Embrace the Blue Ocean Market of Big Health
news The Proteona Oncology Challenge using ESCAPETM Single Cell Proteogenomic Analysis
news New computational fluid dynamics solution for modeling aerosol mixtures in biomedical and environmental research
news Medial Fair Thailand opened on 11th September 2019 with a focus on future-proofing Thailand's healthcare industry to meet the challenges and opportunities of the next decade
PR NEWSWIRE  
Asia Pacific Biotech News
SPOTLIGHT  
LIFE OF A SCIENTIST  

APBN Editorial Calendar 2019
January:
Taiwan Medical tourism
February:
Marijuana as medicine — Legal marijuana will open up scientific research
March:
Driven by curiosity
April:
Career developments for researchers
May:
What's cracking — Antibodies in ostrich eggs
June:
Clinical trials — What's in a name?
July:
Traditional Chinese medicine in modern healthcare — Integrating both worlds
August:
Digitalization vs Digitization — Exploring Emerging Trends in Healthcare
September:
Healthy Ageing — How Science is chipping in
October:
Disruptive Urban Farming — Microbes, Plasmids, and Recycling
November:
Evaluating cost effectiveness of genomic profiling
Editorial calendar is subjected to changes.
MAGAZINE TAGS
About Us
Events
Available issues
Editorial Board
Letters to Editor
Instructions to Authors
Advertise with Us
CONTACT
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
Tel: 65-6466-5775
Fax: 65-6467-7667
» For Editorial Enquiries:
   biotech_edit@wspc.com or Ms Deborah Seah
» For Subscriptions, Advertisements &
   Media Partnerships Enquiries:
   biotech_ad@wspc.com
Copyright© 2019 World Scientific Publishing Co Pte Ltd  •  Privacy Policy